Exercise-mediated neurogenesis in the hippocampus via BDNF

PZ Liu, R Nusslock - Frontiers in neuroscience, 2018 - frontiersin.org
Exercise is known to have numerous neuroprotective and cognitive benefits, especially
pertaining to memory and learning related processes. One potential link connecting them is …

Actions of brain-derived neurotrophin factor in the neurogenesis and neuronal function, and its involvement in the pathophysiology of brain diseases

T Numakawa, H Odaka, N Adachi - International journal of molecular …, 2018 - mdpi.com
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a
variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the …

Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling

C Phillips, MA Baktir, M Srivatsan… - Frontiers in cellular …, 2014 - frontiersin.org
While the relationship between increased physical activity and cognitive ability has been
conjectured for centuries, only recently have the mechanisms underlying this relationship …

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

RS Duman, B Voleti - Trends in neurosciences, 2012 - cell.com
Basic and clinical studies demonstrate that stress and depression are associated with
atrophy and loss of neurons and glia, which contribute to the decreased size and function of …

Brain-derived neurotrophic factor and major depressive disorder: evidence from meta-analyses

T Kishi, R Yoshimura, T Ikuta, N Iwata - Frontiers in psychiatry, 2018 - frontiersin.org
Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is
associated with the pathophysiology of major depressive disorder (MDD). In this mini review …

An excitatory synapse hypothesis of depression

SM Thompson, AJ Kallarackal, MD Kvarta… - Trends in …, 2015 - cell.com
Depression is a common cause of mortality and morbidity, but the biological bases of the
deficits in emotional and cognitive processing remain incompletely understood. Current …

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy

M Notaras, R Hill, M van den Buuse - Molecular psychiatry, 2015 - nature.com
Brain-derived neurotrophic factor (BDNF) has a primary role in neuronal development,
differentiation and plasticity in both the developing and adult brain. A single-nucleotide …

[HTML][HTML] Pleiotropic effects of BDNF on the cerebellum and hippocampus: Implications for neurodevelopmental disorders

S Camuso, P La Rosa, MT Fiorenza, S Canterini - Neurobiology of disease, 2022 - Elsevier
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
mammalian brain, essential not only to the development of the central nervous system but …

[HTML][HTML] Brain-derived neurotrophic factor: three ligands, many actions

BL Hempstead - Transactions of the American Clinical and …, 2015 - ncbi.nlm.nih.gov
Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which
include nerve growth factor, neurotrophin 3, and neurotrophin 4. Studies over the last three …

A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation

M Aas, P Dazzan, V Mondelli, I Melle… - Frontiers in …, 2014 - frontiersin.org
Objective: To carry out a systematic review of the literature addressing cognitive functions in
first-episode psychosis (FEP), divided into domains. Although this is not a full “cognitive …