Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis
ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
[HTML][HTML] The Structure–Antiproliferative Activity Relationship of Pyridine Derivatives
AL Villa-Reyna, M Perez-Velazquez… - International Journal of …, 2024 - mdpi.com
Pyridine, a compound with a heterocyclic structure, is a key player in medicinal chemistry
and drug design. It is widely used as a framework for the design of biologically active …
and drug design. It is widely used as a framework for the design of biologically active …
Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies
Inhibition of high cholinesterase levels including acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
Inhibitory effects of honey from arid land on some enzymes and protein damage
Although arid land honey is outstanding for its conventional uses in food and medicine,
there is an absence of data regarding its health benefits from the perspective of enzyme …
there is an absence of data regarding its health benefits from the perspective of enzyme …
Recent developments in the design and synthesis of benzylpyridinium salts: Mimicking donepezil hydrochloride in the treatment of Alzheimer's disease
Background: Alzheimer's disease (AD) is an advanced and irreversible degenerative
disease of the brain, recognized as the key reason for dementia among elderly people. The …
disease of the brain, recognized as the key reason for dementia among elderly people. The …
Synthesis, anticholinesterase activity, molecular docking, and molecular dynamic simulation studies of 1, 3, 4‐oxadiazole derivatives
Abstract Two new series of 1, 3, 4‐oxadiazoles bearing pyridine and thiazole heterocycles
(4a‐h and 5a‐h) were synthesized (2, 5‐disubstituted‐1, 3, 4‐oxadiazoles). The structures of …
(4a‐h and 5a‐h) were synthesized (2, 5‐disubstituted‐1, 3, 4‐oxadiazoles). The structures of …
Drug candidates for the treatment of Alzheimer's disease: New findings from 2021 and 2022
SL Motebennur, BP Nandeshwarappa… - Drugs and Drug …, 2023 - mdpi.com
Alzheimer's disease (AD), an ongoing neurodegenerative disorder among the elderly, is
signalized by amnesia, progressive deficiency in cognitive roles, and behavioral deformity …
signalized by amnesia, progressive deficiency in cognitive roles, and behavioral deformity …
Design, Synthesis, and Assay of New N-acyl-4-(4-aminoalkoxy-phenyl)-thiazole-2-amine Derivatives as Acetylcholinesterase Inhibitors
C Han, PP Shang, Y Xu, BB Wei… - Letters in Drug …, 2023 - ingentaconnect.com
Background: Thiazoles are an important class of heterocyclic compounds with many
biological effects, including anticholinesterase activity. Objective: The purpose of this work …
biological effects, including anticholinesterase activity. Objective: The purpose of this work …