The role of oxidative stress in the pathogenesis of infections with coronaviruses

C Gain, S Song, T Angtuaco, S Satta… - Frontiers in …, 2023 - frontiersin.org
Coronaviruses can cause serious respiratory tract infections and may also impact other end
organs such as the central nervous system, the lung and the heart. The coronavirus disease …

Integrative physiology of pneumonia

LJ Quinton, AJ Walkey, JP Mizgerd - Physiological reviews, 2018 - journals.physiology.org
Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Caveolin-1 identified as a key mediator of acute lung injury using bioinformatics and functional research

L Qu, Y Li, C Chen, T Yin, Q Fang, Y Zhao, W Lv… - Cell Death & …, 2022 - nature.com
Acute lung injury (ALI) is a potentially life-threatening, devastating disease with an extremely
high rate of mortality. The underlying mechanism of ALI is currently unclear. In this study, we …

Caveolin-1 in endothelial cells: A potential therapeutic target for atherosclerosis

Y Shu, S Jin - Heliyon, 2023 - cell.com
Atherosclerosis (AS) is a chronic vascular disease characterized by lipid accumulation and
the activation of the inflammatory response; it remains the leading nation-wide cause of …

Caveolin‐1 negatively regulates inflammation and fibrosis in silicosis

RL He, XN Yuan, X Lv, QX Liu, LJ Tao… - Journal of cellular and …, 2022 - Wiley Online Library
Inhalation of crystalline silica causes silicosis, the most common and serious occupational
disease, which is characterized by progressive lung inflammation and fibrosis. Recent …

Caveolin-1: A Review of Intracellular Functions, Tissue-Specific Roles, and Epithelial Tight Junction Regulation

CM Dalton, C Schlegel, CJ Hunter - Biology, 2023 - mdpi.com
Simple Summary Caveolin-1 (Cav1) is a protein that exists in many different forms and
locations in cells and tissues throughout the body. We can understand more about cell …

Reactive Oxygen Species and Strategies for Antioxidant Intervention in Acute Respiratory Distress Syndrome

EY Lim, SY Lee, HS Shin, GD Kim - Antioxidants, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition
characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of …

The critical roles of caveolin-1 in lung diseases

J Fan, S Zheng, M Wang, X Yuan - Frontiers in Pharmacology, 2024 - frontiersin.org
Caveolin-1 (Cav-1), a structural and functional component in the caveolae, plays a critical
role in transcytosis, endocytosis, and signal transduction. Cav-1 has been implicated in the …

Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia

J Ren, X Xu, Q Wang, SY Ren, M Dong… - Journal of molecular and …, 2016 - Elsevier
Background Adiponectin (APN), an adipose-derived adipokine, alleviates
lipopolysaccharide (LPS)-induced injury in multiple organs including hearts although the …