Nitric oxide is generated from nitric oxide synthase following hyperglycemia-induced
oxidative stress during the course of diabetes mellitus (DM). We examined the temporal …

Introduction. While most animals of the Muridae family are nocturnal, the gerbil displays
diurnal activity and provides a useful model for visual system research. The purpose of this …

Current amyloid beta-targeting approaches for Alzheimer's disease (AD) therapeutics only
slow cognitive decline for small numbers of patients. This limited efficacy exists because AD …

Background The age at onset (AO) of Machado-Joseph disease (SCA3/MJD), a disorder
due to an expanded CAG repeat (CAGexp) in ATXN3, is quite variable and the role of …

Introduction. Nitric oxide (NO) is present in various cell types in the central nervous system
and plays a crucial role in the control of various cellular functions. The diurnal Mongolian …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease
characterised by progressive degeneration of the motor neurones. An expanded GGGGCC …

Oxid dusnatý je molekula s významným pleotropným účinkom v organizme, schopná
pôsobiť ako voľný radikál a súčasne aj ako biologická signálna molekula. Zaraďujeme ju …

Psychiatric diseases are varied and their prevalence is increasing overtime at global level.
Biological basis involved in the initiation and progression of psychiatric diseases remain to …

Bipolar disorder (BD) is recognized by the American Heart Association as a condition that
predisposes youth to early-onset cardiovascular disease. The magnitude of this prematurity …

Z historického hľadiska je za objaviteľa oxidu dusnatého (NO) považovaný anglický filozof a
chemik Joseph Priestley, ktorý už v roku 1772 identifikoval túto molekulu a opísal jej …