Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

The mitochondrial electron transport chain (ETC) enables many metabolic processes, but
why its inhibition suppresses cell proliferation is unclear. It is also not well understood why …

Mitochondria play a key role in maintaining energy homeostasis in metabolic tissues,
including adipose tissues. The two main types of adipose tissues are the white adipose …

Mitochondria have primarily been viewed as bioenergetic and biosynthetic organelles that
autonomously co-exist within the cell. However, the past two decades have provided …

We used BioID, a proximity-dependent biotinylation assay with 100 mitochondrial baits from
all mitochondrial sub-compartments, to create a high-resolution human mitochondrial …

Mitochondria are essential for numerous cellular processes, yet hundreds of their proteins
lack robust functional annotation. To reveal functions for these proteins (termed MXPs), we …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

Endothelial cells (ECs) require glycolysis for proliferation and migration during
angiogenesis; however, the necessity for the mitochondrial respiratory chain during …

Mitochondrial dysfunction affects cellular energy metabolism, but less is known about the
consequences for cytoplasmic biosynthetic reactions. We report that mtDNA replication …