Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate
chains that endow articular cartilage with its ability to withstand compressive loads. It is …

The anatomic forms of diarthrodial joints are important structural features which provide and
limit the motions required for the joint. Typically, the length scale of topographic variation of …

Chondroitin sulfate (CS) being a natural glycosaminoglycan is found in the cartilage and
extracellular matrix. It shows clinical benefits in symptomatic osteoarthritis (OA) of the finger …

Autologous chondrocyte implantation is being used increasingly for the treatment of
cartilage defects. In spite of this, there has been a paucity of objective, standardised …

Proteoglycans are key components of extracellular matrices, providing structural support as
well as influencing cellular behaviour in physiological and pathological processes. The …

This study provides a unique correlation between a molecular biological and biochemical
analysis of the extracellular matrix (ECM) macromolecules in one half of 28 human Achilles …

OBJECTIVE:: The integrity of articular cartilage is maintained by the balance between
cytokine-driven anabolic and catabolic processes. Unregulated or excess influences of …

Chondroitin sulfate (CS) is recommended as a therapeutic intervention in the multimodal
approach of osteoarthritis (OA) management. CS has been studied extensively to describe …

Changes in the structure of the proteoglycan aggrecan (PG) of articular cartilage were
determined immunochemically by RIA and gel chromatography and related to cartilage …

Intervertebral discs allow bending and twisting of the spine whilst resisting compression from
gravity and muscle action, and are composite structures of the peripheral annulus fibrosus …