The eukaryotic genome is organized at varying levels into chromosome territories,
transcriptional compartments and topologically associating domains (TADs), which are …

Two forms of X-chromosome inactivation (XCI) ensure the selective silencing of female sex
chromosomes during mouse embryogenesis. Imprinted XCI begins with the detection of Xist …

The incidence of pancreatic ductal adenocarcinoma (PDAC) nearly equals its mortality rate,
partly because most PDACs are intrinsically chemoresistant and thus largely untreatable. It …

Gene regulatory networks controlling functional activities of spatially and temporally distinct
endodermal cell populations in the early mouse embryo remain ill defined. The T-box …

Transcription activation is the foremost step of gene expression and is modulated by various
factors that act in synergy. Misregulation of this process and its associated factors has …

The natural product family of the fusicoccanes (FCs) has been shown to display anti-cancer
activity, especially when combined with established therapeutic agents. FCs stabilize 14-3-3 …

Cardiac stem/progenitor cells hold great potential for regenerative therapies; however, the
mechanisms regulating their expansion and differentiation remain insufficiently defined …

LIM transcription factors bind to nuclear LIM interactor (Ldb/NLI/Clim) in specific ratios to
form higher-order complexes that regulate gene expression. Here we examined how the …

Mammalian X-linked gene expression is highly regulated as female cells contain two and
male one X chromosome (X). To adjust the X gene dosage between genders, female mouse …

Mammary oncogenesis is profoundly influenced by signaling pathways controlled by
estrogen receptor α (ERα). Although it is known that ERα exerts its oncogenic effect by …