An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities

ON Silva, C De La Fuente-Núñez, EF Haney… - Scientific reports, 2016 - nature.com
Antibiotic-resistant infections are predicted to kill 10 million people per year by 2050, costing
the global economy $100 trillion. Therefore, there is an urgent need to develop alternative …

Cn‐AMP1: A new promiscuous peptide with potential for microbial infections treatment

ON Silva, WF Porto, L Migliolo, SM Mandal… - Peptide …, 2012 - Wiley Online Library
The antimicrobial peptides (AMPs) are evolutionarily ancient molecules that act as
components of the innate immune system. Recently, it was demonstrated that a single AMP …

Characterization and Pharmacological Properties of a Novel Multifunctional Kunitz Inhibitor from Erythrina velutina Seeds

RJA Machado, NKV Monteiro, L Migliolo, ON Silva… - PLoS …, 2013 - journals.plos.org
Inhibitors of peptidases isolated from leguminous seeds have been studied for their
pharmacological properties. The present study focused on purification, biochemical …

JcTI-I: a novel trypsin inhibitor from Jatropha curcas seed cake with potential for bacterial infection treatment

HPS Costa, JTA Oliveira, DOB Sousa… - Frontiers in …, 2014 - frontiersin.org
Jatropha curcas seed cake is a low-value by-product resulting from biodiesel production.
The seed cake is highly toxic, but it has great potential for biotechnology applications as it is …

Antimicrobial Activity of ILTI, a Kunitz‐Type Trypsin Inhibitor from Inga laurina (SW.) Willd

MLR Macedo, SFF Ribeiro, GB Taveira, VM Gomes… - Current …, 2016 - Springer
Over the last few years, a growing number of proteinase inhibitors have been isolated from
plants and particularly from seeds and have shown antimicrobial activity. A 20,000 Da serine …

Exploiting the biological roles of the trypsin inhibitor from Inga vera seeds: a multifunctional Kunitz inhibitor

C da Silva Bezerra, CFR de Oliveira, OLT Machado… - Process …, 2016 - Elsevier
Here, the purification, biochemical and biological properties of a trypsin inhibitor from Inga
vera seeds (IVTI) are described. Partial amino acid sequence of IVTI showed that it belongs …

[PDF][PDF] Plant serine protease inhibitor (SPI): A potent player with bactericidal, fungicidal, nematicidal and antiviral properties

UN Mishra, MV Reddy, DT Prasad - Int J Chem Stud, 2020 - researchgate.net
This review describes plant originated serine protease inhibitors (SPIs) that target or inhibit
different families of serine proteases (SPs), protein-digesting enzymes of various pathogens …

Purification and characterization of a stable Kunitz trypsin inhibitor from Trigonella foenum-graecum (fenugreek) seeds

R Oddepally, G Sriram, L Guruprasad - Phytochemistry, 2013 - Elsevier
Kunitz trypsin inhibitor was purified from the seeds of Trigonella foenum-graecum (TfgKTI)
belonging to fabaceae family by ammonium sulphate precipitation, cation exchange, gel …

Inhibitory effects of a Kunitz-type inhibitor from Pithecellobium dumosum (Benth) seeds against insect-pests' digestive proteinases

FPS Rufino, VMA Pedroso, JN Araujo… - Plant Physiology and …, 2013 - Elsevier
Pithecellobium dumosum is a tree belonging to the Mimosoideae subfamily that presents
various previously characterized Kunitz-type inhibitors. The present study provides a novel …

Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects

A Karray, M Alonazi, S Smaoui, P Michaud, D Soliman… - Molecules, 2020 - mdpi.com
The main objective of the current study was the extraction, purification, and biochemical
characterization of a protein protease inhibitor from Conyza dioscoridis. Antimicrobial …