Neurodegenerative diseases cause severe impairments in cognitive and motor function.
With an increasing aging population and the onset of these diseases between 50 and 70 …

Different cell channels and transporters tightly regulate cytoplasmic levels and the
intraorganelle distribution of cations. Perturbations in these processes lead to human …

TRPA1 and TRPM8 are transient receptor potential channels expressed in trigeminal
neurons that are related to pathophysiology in migraine models. Here we use a mouse …

It has long been recognized that men and women have different degrees of susceptibility to
chronic pain. Greater recognition of the sexual dimorphism in chronic pain has resulted in …

Steroid hormones bind receptors in the cell nucleus and in the cell membrane. The most
widely studied class of steroid hormone receptors are the nuclear receptors, named for their …

Sensory neurons serve to receive and transmit a wide range of information about the
conditions of the world around us as well as the external and internal state of our body …

Chronic pain is a major burden for the society and remains more prevalent and severe in
females. The presence of chronic pain is linked to persistent alterations in the peripheral and …

Obesity is associated with hypothalamic–pituitary–testicular axis dysregulation in males.
Here, we summarize recent evidence derived from clinical trials and studies in preclinical …

Aging-related reduction in androgen levels may be a possible risk factor for
neurodegenerative diseases and contribute to cognitive impairment. Androgens may affect …

The thermosensory transient receptor potential (thermoTRP) family of ion channels is
constituted by several nonselective cation channels that are activated by physical and …