Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Cancer is a group of diseases responsible for the major causes of mortality and morbidity
among people of all ages. Even though medical sciences have made enormous growth …

Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via
blocking DNA topoisomerase 1. Despite its encouraging and wide-spectrum antitumour …

Tumors are often characterized by hypoxia, vascular abnormalities, low extracellular pH,
increased interstitial fluid pressure, altered choline-phospholipid metabolism, and aerobic …

Drug resistance is one of the significant clinical burden in renal cell carcinoma (RCC). The
development of drug resistance is attributed to many factors, including impairment of …

Thousands of patients die each year from residual cancer that remains following
cytoreductive surgery. Use of tumor-targeted fluorescent dyes (TTFDs) to illuminate …

Mitochondria are important targets in diverse physiological and pathological conditions
associated with cell survival and death. The characterization of mitochondria‐targeting …

Triple negative breast cancer (TNBC) is a highly aggressive tumor subtype, lacking
estrogen, progesterone and human epidermal growth factor-2 (HER-2) receptors. Thus …

Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical
diagnosis, biomedical oncologic research, and drug development process, which include …

Hypoxia is a common feature of solid tumors contributing to resistance to chemotherapy.
Selective delivery of chemotherapeutic drugs to hypoxic tumor niche remains an unsolved …