Over the past decade, epigenetic clocks have emerged as powerful machine learning tools,
not only to estimate chronological and biological age but also to assess the efficacy of anti …

Background During aging, the human methylome undergoes both differential and variable
shifts, accompanied by increased entropy. The distinction between variably methylated …

The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

DNA methylation clocks can accurately estimate chronological age and, to some extent, also
biological age, yet the process by which age-associated DNA methylation (DNAm) changes …

Senolytics, small molecules targeting cellular senescence, have emerged as potential
therapeutics to enhance health span. However, their impact on epigenetic age remains …

Defining the number and abundance of different cell types in tissues is important for
understanding disease mechanisms as well as for diagnostic and prognostic purposes …

Background Geroscience focuses on interventions to mitigate molecular changes
associated with aging. Lifestyle modifications, medications, and social factors influence the …

The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to
be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) …

The ability to accurately quantify biological age could help monitor and control healthy
aging. Epigenetic clocks have emerged as promising tools for estimating biological age, yet …

Background DNA methylation (DNAm), an epigenetic mechanism that regulates gene
activity in response to genetic and environmental influences, changes as we age. DNAm at …