Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

Tauopathies consist of over 25 different neurodegenerative diseases that include
argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal …

The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Acute myeloid leukemia (AML) is a devastating disease, with the majority of patients dying
within a year of diagnosis. For patients with relapsed/refractory AML, the prognosis is …

The human genome functions as a three-dimensional chromatin polymer, driven by a
complex collection of chromosome interactions,–. Although the molecular rules governing …

The effective treatment of acute myeloid leukemia (AML) is very challenging. Due to the
immense heterogeneity of this disease, treating it using a “one size fits all” approach is …

GSK3 has been implicated for years in the regulation of inflammation and addressed in a
plethora of scientific reports using a variety of experimental (disease) models and …

Alzheimer's disease (AD), like other multifactorial diseases, is the result of a systemic
breakdown of different physiological networks. As result, several lines of evidence suggest …

Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to
public health. There is currently no adequate therapy for these disorders, and therefore there …

Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …