Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …

Abstract Gain of chromosome 1q (+ 1q) is one of the most common recurrent cytogenetic
abnormalities in multiple myeloma (MM), occurring in approximately 40% of newly …

BACKGROUND: Persistent inflammation has been proposed to contribute to various stages
in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling …

Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the
etiology of several chronic diseases. Although a common, non-synonymous variant in the IL …

Although TNFRSF 17 (also designated as B‐cell maturation antigen (BCMA)) is expressed
on tumour cells in B‐cell malignancies, it has not been found in serum. The present study …

Simple Summary Multiple myeloma (MM), a plasma cell neoplasm, is an incurable
hematological malignancy. Gain/amplification of chromosome arm 1q21 (1q21+) is the most …

Accompanied by the growing clinical applications of immunotherapy in the treatment of
cancer patients, development of novel therapeutic approaches to reverse the immune …

Amplification of 1q21 occurs in approximately 30% of de novo and 70% of relapsed multiple
myeloma (MM) and is correlated with disease progression and drug resistance. Here, we …

Proteolytic cleavage of transmembrane proteins is an important post-translational
modification that regulates the biological function of numerous transmembrane proteins …

The pleiotropic cytokine interleukin-6 (IL-6) is involved in numerous physiological and
pathophysiological functions that include development, immune cell differentiation …