Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties
Antibody drugs should exhibit not only high-binding affinity for their target antigens but also
favorable physicochemical drug-like properties. Such drug-like biophysical properties are …
favorable physicochemical drug-like properties. Such drug-like biophysical properties are …
Combined effect of shaking orbit and vial orientation on the agitation-induced aggregation of proteins
S Dasnoy, M Illartin, J Queffelec, A Nkunku… - Journal of …, 2024 - Elsevier
Orbital shaking in a glass vial is a commonly used forced degradation test to evaluate
protein propensity for agitation-induced aggregation. Vial shaking in horizontal orientation …
protein propensity for agitation-induced aggregation. Vial shaking in horizontal orientation …
A Versatile, Low-Cost Modular Microfluidic System to Prepare Poly (Lactic-co-Glycolic Acid) Nanoparticles With Encapsulated Protein
MA Neustrup, THM Ottenhoff, W Jiskoot… - Pharmaceutical …, 2024 - Springer
Objective Microfluidics has emerged as a promising technique to prepare nanoparticles.
However, the current microfluidic devices are mainly chip-based and are often integrated …
However, the current microfluidic devices are mainly chip-based and are often integrated …
Three-Dimensional Homodyne Light Detection (3D-HLD) for High-Throughput Submicron Particle Analysis in (Highly Concentrated) Protein Biopharmaceuticals, Viral …
D Brandstetter, C Helbig, K Osawa, H Minemura… - Journal of …, 2024 - Elsevier
During biopharmaceutical development, particle monitoring and characterization are crucial.
Notably, particles can be impurities considered as critical quality attribute, or active …
Notably, particles can be impurities considered as critical quality attribute, or active …