Metformin is a wonder drug used as an anti-hypoglycemic medication; it is also used as a
cancer suppression medicament. Metformin is a first line of drug choice used by doctors for …

Metformin, a cheap and safe biguanide derivative, due to its ability to influence metabolism,
is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of …

Since the UK Prospective Diabetes Study (UKPDS), metformin has been considered the first-
line medication for patients with newly diagnosed type 2 diabetes. Though direct evidence …

In recent years, there has been a dramatic increase in the number of pregnancies
complicated by gestational diabetes mellitus (GDM). GDM occurs when maternal insulin …

Oxidative stress and aberrant insulin signaling transduction play vital roles in type 2
diabetes mellitus (T2DM). Our previous research has demonstrated that trilobatin (TLB) …

Background: The etiology of acute metabolic acidosis (aMA) is heterogeneous, and the
consequences are potentially life-threatening. The aim of this article was to summarize the …

Polymorphisms in SLC22A1 lead to variability in metformin clinical efficacy. Sixty-three
Lebanese patients with type 2 diabetes who administered metformin, were followed up for …

Metformin is the leading drug for treating type 2 diabetics, but the mechanism of action of
metformin, despite some suggested mechanisms such as the activation of the AMP-kinase …

Background: Diabetes Mellitus is a metabolite disorder with parameters of high blood sugar
levels. In the management of diabetes can be used the drug metformin is the gold of choice …

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in
various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) …