Functional genomics data: privacy risk assessment and technological mitigation

G Gürsoy, T Li, S Liu, E Ni, CM Brannon… - Nature Reviews …, 2022 - nature.com
The generation of functional genomics data by next-generation sequencing has increased
greatly in the past decade. Broad sharing of these data is essential for research …

Over 100x faster bootstrapping in fully homomorphic encryption through memory-centric optimization with GPUs

W Jung, S Kim, JH Ahn, JH Cheon… - IACR Transactions on …, 2021 - tches.iacr.org
Fully Homomorphic encryption (FHE) has been gaining in popularity as an emerging means
of enabling an unlimited number of operations in an encrypted message without decryption …

Secure large-scale genome-wide association studies using homomorphic encryption

M Blatt, A Gusev, Y Polyakov… - Proceedings of the …, 2020 - National Acad Sciences
Genome-wide association studies (GWASs) seek to identify genetic variants associated with
a trait, and have been a powerful approach for understanding complex diseases. A critical …

The evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition

TT Kuo, X Jiang, H Tang, XF Wang… - Journal of the …, 2022 - academic.oup.com
Concerns regarding inappropriate leakage of sensitive personal information as well as
unauthorized data use are increasing with the growth of genomic data repositories …

Emerging technologies towards enhancing privacy in genomic data sharing

B Berger, H Cho - Genome biology, 2019 - Springer
As the scale of genomic and health-related data explodes and our understanding of these
data matures, the privacy of the individuals behind the data is increasingly at stake …

Sketching algorithms for genomic data analysis and querying in a secure enclave

C Kockan, K Zhu, N Dokmai, N Karpov, MO Kulekci… - Nature …, 2020 - nature.com
Genome-wide association studies (GWAS), especially on rare diseases, may necessitate
exchange of sensitive genomic data between multiple institutions. Since genomic data …

TrustGWAS: A full-process workflow for encrypted GWAS using multi-key homomorphic encryption and pseudorandom number perturbation

M Yang, C Zhang, X Wang, X Liu, S Li, J Huang… - Cell Systems, 2022 - cell.com
The statistical power of genome-wide association studies (GWASs) is affected by the
effective sample size. However, the privacy and security concerns associated with individual …

iDASH secure genome analysis competition 2018: blockchain genomic data access logging, homomorphic encryption on GWAS, and DNA segment searching

TT Kuo, X Jiang, H Tang, XF Wang, T Bath, D Bu… - BMC medical …, 2020 - Springer
Introduction Auditing data access behavior on genomic data repositories, such as GTEx, is
needed because the mismatching of the proposed and the actual data usage should be …

Privacy-preserving construction of generalized linear mixed model for biomedical computation

R Zhu, C Jiang, X Wang, S Wang, H Zheng… - …, 2020 - academic.oup.com
Motivation The generalized linear mixed model (GLMM) is an extension of the generalized
linear model (GLM) in which the linear predictor takes random effects into account. Given its …

Optimized homomorphic encryption solution for secure genome-wide association studies

M Blatt, A Gusev, Y Polyakov, K Rohloff… - BMC Medical …, 2020 - Springer
Abstract Background Genome-Wide Association Studies (GWAS) refer to observational
studies of a genome-wide set of genetic variants across many individuals to see if any …