Synthesis of biologically active heterocycles via a domino sequence involving an SN2/Thorpe–Ziegler Reaction Step

NA Larionova, AM Shestopalov, LA Rodinovskaya… - …, 2022 - thieme-connect.com
This review highlights methods for the synthesis of five-and six-membered heterocycles and
their annulated analogues. These methods are based on anionic domino reactions that …

A mechanistic insight into the acid catalyzed, one-pot synthesis of isoindole-fused quinazolin 4-ones

MA Mondal, S Mondal, AA Khan - Journal of Chemical Sciences, 2020 - Springer
One-pot synthesis of isoindole fused quinazolin 4-ones via intramolecular 1, 3 hydride
transfer in the presence of acid catalyst has been described. Substrate scope and …

Synthesis of Dibenzo[b,e][1,4]Diazepine Derivatives

KM El-Shaieb, AA Hassan… - Journal of Chemical …, 2011 - journals.sagepub.com
The reaction of (Z)-2-amino-N '-arylbenzamidines with both 2, 3-dichloro-5, 6-dicyano-1, 4-
benzoquinone and 2, 3, 5, 6-tetrachloro-1, 4-benzoquinone have been studied. The …

Synthesis of 1, 2, 4-triazepine and 1, 2, 5-triazocine derivatives from the reaction of 2-aminobenzohydrazide with π-acceptors

KM El-Shaieb, MA Ameen… - Journal of Chemical …, 2012 - journals.sagepub.com
The formation of metal complexes with acid hydrazides plays an important role in the growth
of their biological activity. A simple synthetic strategy is described for the synthesis of novel …

Synthesis of Thiazine and Thiazepine Derivatives from (Z)-2-Cyano-3-Mercapto-3-(Phenylamino)Acrylamide

KM El-Shaieb, FF Abdel-Latif… - Journal of Chemical …, 2012 - journals.sagepub.com
The reaction of (Z)-2-cyano-3-mercapto-3-(phenylamino) acrylamide with
teteracyanoethylene and 2-dicyanomethyleneindan-1, 3-dione gave thiazine derivatives …

Unexpected Formation of 2-Acetyl-3-Aryl-2-Methyl-2,3-Dihydroquinazolin-4(1H)-Ones in the Reaction of 2-Amino-N'-Arylbenzamidines with Butanedione

W Szczepankiewicz, N Kuźnik, S Boncel… - Chemistry of Heterocyclic …, 2014 - Springer
Reactions of 2-amino-N'-arylbenzamidines with butanedione resulted in the formation of 2-
acetyl-3-aryl-2-methyl-2, 3-dihydroquinazolin-4 (1H)-ones instead of the expected 2-acetyl-4 …

The reaction of 2-amino-N′-arylbenzamidines with tetracyanoethene reinvestigated: routes to imidazoles, quinazolines and quinolino [2′, 3′: 4, 5] imidazo [1, 2-c] …

SI Mirallai, M Manoli, PA Koutentis - Tetrahedron, 2015 - Elsevier
Amino-N′-phenylbenzamidine (1a) reacts with tetracyanoethene (TCNE) to give 2-[2-(2-
aminophenyl)-5-imino-1-phenyl-1H-imidazol-4 (5H)-ylidene] malononitrile (11a), 4 …

Solvent-free synthesis of isoindolo [2, 1-c] pyrazolo [1, 5-a] quinazoline and pyrazolo [5′, 1′: 2, 3] pyrimido [6, 1-a] isoindol derivatives through a one-pot three …

M Alizadeh-Kouzehrash, A Rahmati - Molecular Diversity, 2021 - Springer
Abstract Some 5-substituted 3-aminopyrazoles were used for the synthesis of isoindolo [2, 1-
c] pyrazolo [1, 5-a] quinazoline and pyrazolo [5′, 1′: 2, 3] pyrimido [6, 1-a] isoindol …

Synthesis of 4-arylaminoquinazoline-2-carboxylic acid derivatives by the reaction of (Z)-2-amino-N-aryl-benzimidamides with some selected anhydrides

KM El-Shaieb - Zeitschrift für Naturforschung B, 2019 - degruyter.com
Abstract Novel reactions of (Z)-2-amino-N′-arylbenzimidamides (1a, b) are described.
When 1a, b are reacted with diphenic, phthalic and succinic anhydrides, in dry ethyl alcohol …

New chemistry of N'-arylbenzamidines

SI Mirallai - 2015 - gnosis.library.ucy.ac.cy
The Thesis begins with a brief introduction (Chapter 1) on heterocyclic chemistry, which then
focuses on nitrogen heteroaromatics and the use of amidines in the synthesis of imidazoles …