Significance: Optical imaging using the endogenous fluorescence of metabolic cofactors has
enabled nondestructive examination of dynamic changes in cell and tissue function both in …

Tissue engineering has broad and diverse impacts on a variety of different applications from
tissue regeneration to drug screening. While two-dimensional (2-D) cell culture platforms are …

The non-invasive high-resolution spatial mapping of cell metabolism within tissues could
provide substantial advancements in assessing the efficacy of stem cell therapy and …

Monitoring subcellular functional and structural changes associated with metabolism is
essential for understanding healthy tissue development and the progression of numerous …

A major limitation to cardiac tissue engineering and regenerative medicine strategies is the
lack of proliferation of postnatal cardiomyocytes. The extracellular matrix (ECM) is altered …

Alterations in the balance between different metabolic pathways used to meet cellular
bioenergetic and biosynthetic demands are considered hallmarks of cancer. Optical imaging …

Dynamic alterations in the unique brain extracellular matrix (ECM) are involved in malignant
brain tumors. Yet studies of brain ECM roles in tumor cell behavior have been difficult due to …

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-
renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate …

Introduction Although stem cell therapy is a promising treatment for myocardial infarction, the
minimal functional improvements observed clinically limit its widespread application. A need …

In obese adipose tissue (AT), hypertrophic expansion of adipocytes is not matched by new
vessel formation, leading to AT hypoxia. As a result, hypoxia inducible factor-1⍺(HIF-1⍺) …