Immunity and inflammation are key elements of the pathobiology of stroke, a devastating
illness second only to cardiac ischemia as a cause of death worldwide. The immune system …

Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …

Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

Stroke seriously threatens human health because of its characteristics of high morbidity,
disability, recurrence, and mortality, thus representing a heavy financial and mental burden …

Stroke is a brain disease that occurs when blood flow stops, resulting in reduced oxygen
supply to neurons. Stroke occurs at any time and at any age, but increases after the age of …

A variety of animal models have been developed for modeling ischemic stroke. The middle
cerebral artery occlusion (MCAO) model has been utilized extensively, especially in rodents …

Sex differences in stroke are observed across epidemiologic studies, pathophysiology,
treatments, and outcomes. These sex differences have profound implications for effective …

The search of effective anti-stroke neuroprotectors requires various stroke models adequate
for different aspects of the ischemic processes. The photothrombotic stroke model is …

Oleic acid (OA) is released from brain phospholipids after cerebral ischaemia; however, its
role in ischaemic injury remains unknown. We hypothesised that OA has neuroprotective …