Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Nuclear envelope spectrin-repeat proteins (Nesprins), are a novel family of nuclear and
cytoskeletal proteins with rapidly expanding roles as intracellular scaffolds and linkers …

The nucleus of a cell has long been considered to be subject to mechanical force. Despite
the observation that mechanical forces affect nuclear geometry and movement, how forces …

Endothelial cells line all blood vessels, where they coordinate blood vessel formation and
the blood-tissue barrier via regulation of cell-cell junctions. The nucleus also regulates …

The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by
linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from …

Cell nuclei are physically integrated with the cytoskeleton through the linker of
nucleoskeleton and cytoskeleton (LINC) complex, a structure that spans the nuclear …

Abstract Nesprins-1/-2/-3/-4 are nuclear envelope proteins, which connect nuclei to the
cytoskeleton. The largest nesprin-1/-2 isoforms (termed giant) tether F-actin through their N …

Biophysical stimuli presented to cells via microenvironmental properties (eg, alignment and
stiffness) or external forces have a significant impact on cell function and behavior. Recently …

Haploid spermatids undergo extensive cellular, molecular and morphological changes to
form spermatozoa during spermiogenesis. Abnormalities in these steps can lead to serious …

The nuclear membrane serves a critical role in protecting the contents of the nucleus and
facilitating material and signal exchange between the nucleus and cytoplasm. While …