CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Chemokines are important proteins involved in the regulation of directed leukocyte migration
during inflammation and the homeostatic homing of immune cells. In addition, they play a …

A variety of molecules in human blood have been implicated in the inhibition of HIV-1.
However, it remained elusive which circulating natural compounds are most effective in …

CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is
associated with cancers and inflammatory diseases. To discover as-yet-unknown …

Nef is a multifunctional accessory protein of primate lentiviruses. Recently, it has been
shown that the ability of Nef to downmodulate CD4, CD28, and class I major …

We investigated the infectivities and replicative capacities of a large panel of variants of the
molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively …

The placenta acts as physical and immunological barrier against the transmission of viruses
and bacteria from mother to fetus. However, the specific mechanisms by which the placenta …

Infectious diseases and cancers are leading causes of death and pose major challenges to
public health. The human peptidome encompasses millions of compounds that display an …

ABSTRACT A subset of HIV-infected individuals termed elite controllers (ECs) maintain
CD4+ T cell counts and control viral replication in the absence of antiretroviral therapy …

Rheumatoid arthritis (RA) is a destructive and chronic autoimmune inflammatory disease.
Synovial inflammation is a major feature of RA and is associated with leukocyte recruitment …