Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …

The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …

Previous studies have shown that insulin and IGF-1 signaling in the brain, especially the
hypothalamus, is important for regulation of systemic metabolism. Here, we develop mice in …

Cholesterol is a crucial component of membrane bilayers by regulating their structural and
functional properties. Cholesterol traffics to different cellular compartments including …

Since its discovery over 100 years ago, insulin has been recognized as a key hormone in
control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and …

Cholesterol is important for normal brain function. The brain synthesizes its own cholesterol,
presumably in astrocytes. We have previously shown that diabetes results in decreased …

Sterol regulator element binding proteins (SREBPs) are a family of transcription factors
involved in the biogenesis of cholesterol, fatty acids and triglycerides. They also regulate …

Cholesterol is an important constituent of cell membranes and plays a crucial role in the
compartmentalization of the plasma membrane and signaling. Brain cholesterol accounts for …

Importance DNA methylation may play an important role in schizophrenia (SZ), either
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …