Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Simple Summary The tumor microenvironment (TME) is a complicated network composed of
various cells, signaling molecules, and extra cellular matrix. TME plays a crucial role in triple …

Exosomes are associated with the development and progression of Alzheimer's disease
(AD), although the impact of these extracellular vesicles in brain pathological condition …

Background Atractylenolide-1, an active component of Atractylodes Lancea, which is widely
used to improve the gastrointestinal function. However, the efficacy and mechanism remain …

Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

Background In addition to potent agonist properties for sphingosine 1‐phosphate (S1P)
receptors, intracellularly, S1P is an intermediate in metabolic conversion pathway from …

Abstract Sphingosine kinase 1 (SphK1) has recently gained attention as a potential drug
target for its association with cancer and other inflammatory diseases. Here, we have …

Epithelial-to-mesenchymal transition (EMT) is a process through which epithelial cells lose
their epithelial characteristics and cell–cell contact, thus increasing their invasive potential …

Morbidity of inflammatory gastrointestinal (GI) diseases continues to grow resulting in
worsen quality of life and increased burden on public medical systems. Complex and …

Esophageal adenocarcinoma (EAC) is the sixth leading cause of cancer deaths worldwide
and has been dramatically increasing in incidence over the past decade. Gastroesophageal …