EGFR in cancer: Signaling mechanisms, drugs, and acquired resistance

ML Uribe, I Marrocco, Y Yarden - Cancers, 2021 - mdpi.com
Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

Y Enuka, M Lauriola, ME Feldman… - Nucleic acids …, 2016 - academic.oup.com
Circular RNAs (circRNAs) are widespread circles of non-coding RNAs with largely unknown
function. Because stimulation of mammary cells with the epidermal growth factor (EGF) …

Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain

H Liu, Q Zeng, J Zhou, A Bartlett, BA Wang, P Berube… - Nature, 2023 - nature.com
Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

Context specificity of the EMT transcriptional response

DP Cook, BC Vanderhyden - Nature communications, 2020 - nature.com
Epithelial–mesenchymal plasticity contributes to many biological processes, including tumor
progression. Various epithelial–mesenchymal transition (EMT) responses have been …

Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex

AA Pollen, TJ Nowakowski, J Shuga, X Wang… - Nature …, 2014 - nature.com
Large-scale surveys of single-cell gene expression have the potential to reveal rare cell
populations and lineage relationships but require efficient methods for cell capture and …

A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis

TS Gujral, M Chan, L Peshkin, PK Sorger… - Cell, 2014 - cell.com
Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this
network have been broadly implicated in colorectal cancer. We find that the Wnt receptor …

Rho GTP ases control specific cytoskeleton‐dependent functions of hematopoietic stem cells

RC Nayak, KH Chang, NS Vaitinadin… - Immunological …, 2013 - Wiley Online Library
The Rho family of guanosine triphosphatases (GTP ases) is composed of members of the
Ras superfamily of proteins. They are GTP‐bound molecules with a modest intrinsic GTP …

EGR1-mediated transcription of lncRNA-HNF1A-AS1 promotes cell-cycle progression in gastric cancer

HT Liu, S Liu, L Liu, RR Ma, P Gao - Cancer research, 2018 - AACR
Long noncoding RNAs (lncRNA) are dysregulated in various human cancers and control
tumor development and progression. However, the upstream mechanisms underlying their …

[HTML][HTML] Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9+ renal tubular cells

JW Chen, MJ Huang, XN Chen, LL Wu, QG Li… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Acute kidney injury (AKI) is associated with damage to the nephrons and
tubular epithelial cells (TECs), which can lead to chronic kidney disease and end-stage …

Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy

PJ Williams, JN Bulmer, RF Searle, BA Innes… - …, 2009 - rep.bioscientifica.com
Two experiments using Spanish Merino ewes were conducted to investigate whether the
secretion of prolactin during the follicular phase of the sheep oestrous cycle was involved in …