Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

X Li, M Han, H Zhang, F Liu, Y Pan, J Zhu, Z Liao… - Biomarker …, 2022 - Springer
Zinc finger proteins are transcription factors with the finger domain, which plays a significant
role in gene regulation. As the largest family of transcription factors in the human genome …

Potential prognostic biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) family members in breast cancer

G Anuraga, WJ Wang, NN Phan, NT An Ton… - Journal of personalized …, 2021 - mdpi.com
Breast cancer remains the most common malignant cancer in women, with a staggering
incidence of two million cases annually worldwide; therefore, it is crucial to explore novel …

Comparison of transcriptomic signatures between Monkeypox‐infected monkey and human cell lines

DTM Xuan, IJ Yeh, CC Wu, CY Su… - Journal of …, 2022 - Wiley Online Library
Monkeypox virus (MPV) is a smallpox‐like virus belonging to the genus Orthopoxvirus of the
family Poxviridae. Unlike smallpox with no animal reservoir identified and patients suffering …

MicroRNA-495: a therapeutic and diagnostic tumor marker

A Maharati, F Tolue Ghasaban, I Akhlaghipour… - Journal of Molecular …, 2023 - Springer
Therapeutic and diagnostic progresses have significantly reduced the mortality rate among
cancer patients during the last decade. However, there is still a high rate of mortality among …

Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing

Y Sakamoto, S Zaha, S Nagasawa… - Nucleic Acids …, 2021 - academic.oup.com
Long-read whole-genome sequencing analysis of DNA methylation would provide useful
information on the chromosomal context of gene expression regulation. Here we describe …

HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer

G Pantelaiou-Prokaki, I Mieczkowska, GE Schmidt… - Clinical …, 2022 - Springer
Background Basal-like breast cancer (BLBC) is one of the most aggressive malignant
diseases in women with an increased metastatic behavior and poor prognosis compared to …

N6-Methyladenosine-Related LncRNAs are potential remodeling indicators in the tumor microenvironment and prognostic markers in osteosarcoma

Z Wu, X Zhang, D Chen, Z Li, X Wu, J Wang… - Frontiers in …, 2022 - frontiersin.org
N6-Adenosine methylation, yielding N6-methyladenosine (m6A), is a reversible epigenetic
modification found in messenger RNAs and long non-coding RNAs (lncRNAs), which affects …

LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression

X Chen, C Jiang, B Qin, G Liu, J Ji, X Sun, M Xu… - Cell death & …, 2017 - nature.com
Long noncoding RNAs (lncRNAs) have important roles in various biological processes. Our
previous work has revealed that dedifferentiation of retinal pigment epithelium (RPE) cells …

Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort

Y Han, KJ Jung, U Kim, CI Jeon, K Lee… - Journal of Translational …, 2023 - Springer
Background Pancreatic cancer is a lethal disease with a high mortality rate. The difficulty of
early diagnosis is one of its primary causes. Therefore, we aimed to discover non-invasive …

Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs

Y Li, M Tan, A Akkari-Henić, L Zhang, M Kip… - Nature Biomedical …, 2024 - nature.com
The functions of non-coding regulatory elements (NCREs), which constitute a major fraction
of the human genome, have not been systematically studied. Here we report a method …