Nanocrystals are a universal formulation approach for improved drug delivery of poorly
water-soluble drug substances. Besides oral application, also topical application of the …

Poor aqueous solubility of active compounds is a major issue in today's drug delivery. In this
study the smartFilm-technology was exploited to improve the dermal penetration efficacy of a …

(1) Background: Extracellular vesicles (EVs) are considered to be efficient nanocarriers for
improved drug delivery and can be derived from mammalian or plant cells. Cucumber …

Curcumin has been extensively studied for its medicinal benefits, though its therapeutic use
is limited by a lack of aqueous solubility and bioavailability. Piperine from black pepper is …

Background Transferosomes (TFS) are ultra-deformable elastic bilayer vesicles that have
previously been used to enhance gradient driven penetration through the skin. This study …

Fungal infections of skin including mycoses are one of the most common infections in skin or
skins. Mycosis is caused by dermatophytes, non-dermatophyte moulds and yeasts. Various …

Objective: This study aimed to investigate the feasibility of using the digital image processing
technique, developed to semi-quantitatively study dermal penetration, to study corneal …

Many active pharmaceutical ingredients (API) possess poor aqueous solubility and thus
lead to poor bioavailability upon oral administration and topical application. Nanocrystals …

Lipid nanoparticles (LN) were invented in the early 1990ties and can be exploited for oral
and topical drug delivery to increase the bioavailability of lipophilic active compounds. The …

(1) Background: The ex vivo porcine ear model is often used for the determination of the
dermal penetration efficacy of chemical compounds. This study investigated the influence of …