Predictive biomarkers for checkpoint inhibitor-based immunotherapy in hepatocellular carcinoma: where do we stand?

A Rizzo, AD Ricci, A Di Federico, G Frega… - Frontiers in …, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) remains the sixth most commonly diagnosed malignancy
worldwide, still representing an important cause of cancer-related death. Over the next few …

Which role for predictors of response to immune checkpoint inhibitors in hepatocellular carcinoma?

A Rizzo, A Cusmai, G Gadaleta-Caldarola… - Expert review of …, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) remains a frequently diagnosed malignancy
worldwide, still representing an important cause of cancer-related death. Recent years have …

First-line immune checkpoint inhibitor-based combinations in unresectable hepatocellular carcinoma: current management and future challenges

A Rizzo, AD Ricci, G Gadaleta-Caldarola… - Expert Review of …, 2021 - Taylor & Francis
Introduction Immunotherapy has recently taken on an extremely important role in medical
oncology, as first-or later-line treatment in several tumor types, and recent years have seen …

PD-L1, TMB, and other potential predictors of response to immunotherapy for hepatocellular carcinoma: how can they assist drug clinical trials?

A Rizzo, AD Ricci - Expert opinion on investigational drugs, 2022 - Taylor & Francis
Introduction Hepatocellular carcinoma (HCC) represents the sixth most commonly
diagnosed malignancy worldwide, accounting for millions of deaths annually. Despite …

Hepatocellular carcinoma: an overview of the changing landscape of treatment options

A Koulouris, C Tsagkaris, V Spyrou… - Journal of …, 2021 - Taylor & Francis
The last three years have seen remarkable progress in comprehending predisposing factors
and upgrading our treatment arsenal concerning hepatocellular carcinoma (HCC). Until …

Lenvatinib plus pembrolizumab: the next frontier for the treatment of hepatocellular carcinoma?

A Rizzo, V Dadduzio, AD Ricci, F Massari… - Expert opinion on …, 2022 - Taylor & Francis
Introduction While sorafenib monotherapy represented the mainstay of medical treatment for
advanced hepatocellular carcinoma (HCC) patients for more than a decade, novel agents …

The immunology of hepatocellular carcinoma

G Lawal, Y Xiao, AA Rahnemai-Azar, DI Tsilimigras… - Vaccines, 2021 - mdpi.com
Liver cancer is the third leading cause of cancer death worldwide. Hepatocellular carcinoma
(HCC) is the most common primary malignant tumor of the liver. Liver resection or …

Atezolizumab in advanced hepatocellular carcinoma: good things come to those who wait

A Rizzo, AD Ricci, G Brandi - Immunotherapy, 2021 - Taylor & Francis
Advanced hepatocellular carcinoma (HCC) patients present poor prognosis. However,
recent years have seen the advent of several novel treatments in this setting, where the role …

Surgical conversion for initially unresectable locally advanced hepatocellular carcinoma using a triple combination of angiogenesis inhibitors, anti-PD-1 antibodies …

J Zhang, X Zhang, H Mu, G Yu, W Xing, L Wang… - Frontiers in …, 2021 - frontiersin.org
Background Recent research has shown that selected patients with initially unresectable
hepatocellular carcinoma (HCC) are able to achieve conversion to resectable disease …

Immunotherapy in liver cancer: overcoming the tolerogenic liver microenvironment

Y Liu, H Yang, T Li, N Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Liver cancer is a major global health concern, ranking among the top causes of cancer-
related deaths worldwide. Despite advances in medical research, the prognosis for liver …