Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

Tight junctions are one mode of cell–cell adhesion in epithelial and endothelial cellular
sheets. They act as a primary barrier to the diffusion of solutes through the intercellular …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Multicellular organisms are separated from the external environment by a layer of epithelial
cells whose integrity is maintained by intercellular junctional complexes composed of tight …

Endothelial cells (ECs) form a unique barrier between the vascular lumen and the vascular
wall. In addition, the endothelium is highly metabolically active. In cardiovascular disease …

A fundamental function of epithelia and endothelia is to separate different compartments
within the organism and to regulate the exchange of substances between them. The tight …

ZO-1, ZO-2, and ZO-3, which contain three PDZ domains (PDZ1 to-3), are concentrated at
tight junctions (TJs) in epithelial cells. TJ strands are mainly composed of two distinct types …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …