Cancer systems biology: a network modeling perspective
PK Kreeger, DA Lauffenburger - Carcinogenesis, 2010 - academic.oup.com
Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …
type and tissue origin but also as a disease involving dysregulation of multiple pathways …
A systems biology view of blood vessel growth and remodelling
Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …
capillaries. This vascular network is not static, but instead dynamically remodels in response …
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility
FT Musuamba, I Skottheim Rusten… - CPT …, 2021 - Wiley Online Library
The value of in silico methods in drug development and evaluation has been demonstrated
repeatedly and convincingly. While their benefits are now unanimously recognized …
repeatedly and convincingly. While their benefits are now unanimously recognized …
Biologically-based mathematical modeling of tumor vasculature and angiogenesis via time-resolved imaging data
Simple Summary The recruitment of new vasculature via angiogenesis is a critical
component of tumor development, which fundamentally influences tumor growth and …
component of tumor development, which fundamentally influences tumor growth and …
Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy
MR Owen, IJ Stamper, M Muthana, GW Richardson… - Cancer research, 2011 - AACR
Tumor hypoxia is associated with low rates of cell proliferation and poor drug delivery,
limiting the efficacy of many conventional therapies such as chemotherapy. Because many …
limiting the efficacy of many conventional therapies such as chemotherapy. Because many …
Mesoscopic and continuum modelling of angiogenesis
Angiogenesis is the formation of new blood vessels from pre-existing ones in response to
chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a …
chemical signals secreted by, for example, a wound or a tumour. In this paper, we propose a …
Computational modeling of solid tumor growth: the avascular stage
In this paper, we present a mathematical model for avascular tumor growth and its numerical
study in two and three dimensions. For this purpose, we use a multiscale model using PDEs …
study in two and three dimensions. For this purpose, we use a multiscale model using PDEs …
Mathematical modeling of glioma invasion: acid-and vasculature mediated go-or-grow dichotomy and the influence of tissue anisotropy
M Conte, C Surulescu - Applied Mathematics and Computation, 2021 - Elsevier
Starting from kinetic transport equations and subcellular dynamics we deduce a multiscale
model for glioma invasion relying on the go-or-grow dichotomy and the influence of …
model for glioma invasion relying on the go-or-grow dichotomy and the influence of …
Systems oncology: towards patient-specific treatment regimes informed by multiscale mathematical modelling
GG Powathil, M Swat, MAJ Chaplain - Seminars in cancer biology, 2015 - Elsevier
The multiscale complexity of cancer as a disease necessitates a corresponding multiscale
modelling approach to produce truly predictive mathematical models capable of improving …
modelling approach to produce truly predictive mathematical models capable of improving …
A multilayer grow-or-go model for GBM: effects of invasive cells and anti-angiogenesis on growth
The recent use of anti-angiogenesis (AA) drugs for the treatment of glioblastoma multiforme
(GBM) has uncovered unusual tumor responses. Here, we derive a new mathematical …
(GBM) has uncovered unusual tumor responses. Here, we derive a new mathematical …