White matter injury in the preterm infant: pathology and mechanisms

SA Back - Acta neuropathologica, 2017 - Springer
The human preterm brain is particularly susceptible to cerebral white matter injury (WMI) that
disrupts the normal progression of developmental myelination. Advances in the care of …

The influence of pain, agitation, and their management on the immature brain

C McPherson, SP Miller, M El-Dib, AN Massaro… - Pediatric …, 2020 - nature.com
Preterm infants are exposed to frequent painful procedures and agitating stimuli over the
many weeks of their hospitalization in the neonatal intensive care unit (NICU). The adverse …

BrainNetCNN: Convolutional neural networks for brain networks; towards predicting neurodevelopment

J Kawahara, CJ Brown, SP Miller, BG Booth, V Chau… - NeuroImage, 2017 - Elsevier
We propose BrainNetCNN, a convolutional neural network (CNN) framework to predict
clinical neurodevelopmental outcomes from brain networks. In contrast to the spatially local …

Brain in congenital heart disease across the lifespan: the cumulative burden of injury

A Marelli, SP Miller, BS Marino, AL Jefferson… - Circulation, 2016 - Am Heart Assoc
The number of patients surviving with congenital heart disease (CHD) has soared over the
last 3 decades. Adults constitute the fastest-growing segment of the CHD population, now …

Origin and dynamics of oligodendrocytes in the developing brain: Implications for perinatal white matter injury

E van Tilborg, CGM de Theije, M van Hal, N Wagenaar… - Glia, 2018 - Wiley Online Library
Infants born prematurely are at high risk to develop white matter injury (WMI), due to
exposure to hypoxic and/or inflammatory insults. Such perinatal insults negatively impact the …

Early procedural pain is associated with regionally-specific alterations in thalamic development in preterm neonates

EG Duerden, RE Grunau, T Guo, J Foong… - Journal of …, 2018 - Soc Neuroscience
Very preterm human neonates are exposed to numerous invasive procedures as part of life-
saving care. Evidence suggests that repetitive neonatal procedural pain precedes long-term …

The influence of early nutrition on brain growth and neurodevelopment in extremely preterm babies: a narrative review

BE Cormack, JE Harding, SP Miller, FH Bloomfield - Nutrients, 2019 - mdpi.com
Extremely preterm babies are at increased risk of less than optimal neurodevelopment
compared with their term-born counterparts. Optimising nutrition is a promising avenue to …

Association of socioeconomic status and brain injury with neurodevelopmental outcomes of very preterm children

I Benavente-Fernández, A Synnes… - JAMA network …, 2019 - jamanetwork.com
Importance Studies of socioeconomic status and neurodevelopmental outcome in very
preterm neonates have not sensitively accounted for brain injury. Objective To determine the …

Neurodevelopmental impairment among extremely preterm infants in the neonatal research network

I Adams-Chapman, RJ Heyne, SB DeMauro… - …, 2018 - publications.aap.org
OBJECTIVES: Evaluate the spectrum of neurodevelopmental outcome in a contemporary
cohort of extremely preterm infants. We hypothesize that the rate of severe …

Preterm brain injury, antenatal triggers, and therapeutics: timing is key

DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …