Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …

A noticeable increase in molecular complexity of drug targets has created an unmet need in
the therapeutic agents that are larger than traditional small molecules. Macrocycles, which …

Functions and properties of native peptides vary from highly specific antibiotics or cytotoxic
antitumor drugs, to hormones, neurotransmitters, immunomodulators, etc. Despite their …

Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as
pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive …

Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …

Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

Sortases are a class of bacterial enzymes that possess transpeptidase activity. It is their
ability to site‐specifically break a peptide bond and then reform a new bond with an …

From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for
the treatment of neuropathic pain. Unfortunately, these peptides suffer from the …

Highlights•The human proteasome is the second largest drug target class.•Few prototypic
proteases are standard tools for the discovery of novel inhibitors.•Peptide protease inhibitors …