The Na+-H+ exchange (NHE) is a major mechanism by which the heart adapts to
intracellular acidosis during ischemia and recovers from the acidosis after reperfusion …

The Na+/H+ exchanger (NHE) is a ubiquitous protein present in mammalian cells. In higher
eukaryotes this integral membrane protein removes one intracellular H+ for one extracellular …

Myocardial stretch produces an increase in developed force (DF) that occurs in two phases:
the first (rapidly occurring) is generally attributed to an increase in myofilament calcium …

Myocardial stretch is a well-known stimulus that leads to hypertrophy. Little is known,
however, about the intracellular pathways involved in the transmission of myocardial stretch …

This study was designed to gain additional insight into the mechanism of the slow force
response (SFR) to stretch of cardiac muscle. SFR and changes in intracellular Na+ …

Studies on the role of mitochondrial fission/fusion (MFF) proteins in the heart have been
initiated recently due to their biological significance in cell metabolism. We hypothesized …

Na–H exchange (NHE) is the primary process by which the cardiac cell extrudes protons
particularly under conditions of intracellular acidosis. Nine isoforms of NHE have now been …

Angiotensin II (ANG II) evokes positive inotropic responses in various species. However, the
effects of this peptide on L-type Ca2+ currents (I Ca) are still controversial. We report in this …

This review summarizes and describes the current evidence addressing how sodium-
glucose cotransporter 2 (SGLT2) inhibitors alter the function of sodium-hydrogen exchanger …

Objective: Stretch induces functional and trophic effects in mammalian myocardium via
various signal transduction pathways. We tested stretch signal transduction on immediate …