Homing endonucleases are encoded by open reading frames that are embedded within
group I, group II and archael introns, as well as inteins (intervening sequences that are …

Bacteriocins are a diverse group of ribosomally synthesized protein antibiotics produced by
most bacteria. They range from small lanthipeptides produced by lactic acid bacteria to …

The structure of I-HmuI, which represents the last family of homing endonucleases without a
defining crystallographic structure, has been determined in complex with its DNA target. A …

Abstract The Vibrio vulnificus nuclease, Vvn, is a non‐specific periplasmic nuclease capable
of digesting DNA and RNA. The crystal structure of Vvn and that of Vvn mutant H80A in …

Combining sequence analysis, structure prediction, and site-directed mutagenesis, we have
investigated the mechanism of catalysis and substrate binding by the apoptotic …

The discovery that two common APOL1 alleles were strongly associated with nondiabetic
kidney diseases in African descent populations led to hope for improved diagnosis and …

Computational docking is a useful tool for predicting macromolecular complexes, which are
often difficult to determine experimentally. Here, we present the DOT2 software suite, an …

The restriction endonuclease (REase) R. KpnI is an orthodox Type IIP enzyme, which binds
to DNA in the absence of metal ions and cleaves the DNA sequence 5′-GGTAC^ C-3′ in …

The bacterial toxin ColE7 bears an HNH motif which has been identified in hundreds of
prokaryotic and eukaryotic endonucleases, involved in DNA homing, restriction, repair, or …

HNH endonucleases in bacteriophages play a variety of roles in the phage lifecycle as key
components of phage DNA packaging machines. The deep-sea thermophilic bacteriophage …