Ras proteins are essential mediators of a multitude of cellular processes, and its
deregulation is frequently associated with cancer appearance, progression, and metastasis …

Simple Summary The PTEN phosphatase is a ubiquitously expressed tumor suppressor,
which inhibits the PI3K/AKT pathway in the cell. The PI3K/AKT pathway is considered to be …

Abstract Phosphoinositide 3-kinases (PI3Ks) modify lipids by the phosphorylation of inositol
phospholipids at the 3′-OH position, thereby participating in signal transduction and …

PIK3CA encodes the class I PI3Kα isoform and is frequently mutated in cancer. Activating
mutations in PIK3CA also cause a range of congenital disorders featuring asymmetric tissue …

Ischemic stroke (IS), predominantly triggered by blockages in cerebral blood flow, is
increasingly recognized as a critical public health issue. The combination of Salvia …

Introduction: Chuanxiong, a traditional Chinese medicine, has been proved to treat a variety
of cardiovascular and cerebrovascular diseases by promoting angiogenesis. However, the …

Abstract The phosphoinositide 3-kinase (PI3K) superfamily includes lipid kinases (PI3Ks
and type III PI4Ks) and a group of PI3K-like Ser/Thr protein kinases (PIKKs: mTOR, ATM …

Acylglycerol kinase (AGK) is a recently discovered mitochondrial lipid kinase, and mutation
of its gene is the fundamental cause of Sengers syndrome. AGK is not only involved in the …

Simple Summary The PI3K/Akt/mTOR pathway plays a crucial role in cancer, including
leukemia. Abnormalities in this pathway drive carcinogenesis by inducing uncontrolled …

Abstract Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining
cardiovascular health and the development of cardiovascular diseases (CVDs). Specifically …