Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves
enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) …

The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

Emerging multi-drug resistance in recent Salmonella Typhi isolates, causative agent of
enteric Typhoid fever, compelled us to investigate alternative therapeutic strategies. The …

With antibiotic resistance mechanisms increasing in diversity and spreading among
bacterial pathogens, the development of new classes of antibacterial agents against …

The range of antibiotic therapy for the control of bacterial infections is becoming increasingly
limited because of the rapid rise in multidrug resistance in clinical bacterial isolates. A few …

Tuberculosis (TB) is the second leading cause of human mortality from infectious diseases
worldwide. The WHO reported 1.3 million deaths and 8.6 million new cases of TB in 2012 …

In recent years, several noncanonical RNA caps derived from cofactors and metabolites
have been identified. Purine-containing RNA caps have been extensively studied, with …

Mur ligases participate in the intracellular path of bacterial peptidoglycan biosynthesis and
constitute attractive, although so far underexploited, targets for antibacterial drug discovery …

Mur ligases play an essential role in the intracellular biosynthesis of bacterial peptidoglycan,
the main component of the bacterial cell wall, and represent attractive targets for the design …