Histone deacetylases (HDACs) have recently emerged as an important target for therapeutic
intervention in cancer and potentially other human diseases. By modulating the acetylation …

Purpose: The purpose of this study was to examine interactions between the proteasome
inhibitor bortezomib (Velcade) and the histone deacetylase (HDAC) inhibitors sodium …

Purpose: Histone deacetylases (HDAC) modulate gene transcription and chromatin
assembly by modifying histones at the posttranscriptional level. HDAC inhibitors have …

We identified CREB3 as a novel HDAC3-interacting protein in a yeast two-hybrid screen for
HDAC3-interacting proteins. Among all class I HDACs, CREB3 specifically interacts with …

Butyrate is a key bacterial metabolite that plays an important and complex role in modulation
of immunity and maintenance of epithelial barriers. Its translation to clinic is limited by poor …

AIM: To investigate the antiproliferative effect of the histone deacetylase (HDAC) inhibitor
MS-275 on cholangiocarcinoma cells alone and in combination with conventional cytostatic …

Chemotherapeutic treatment with combinations of drugs is front-line therapy for many types
of cancer. Combining drugs that target different signaling pathways often lessens adverse …

To date, although a promising anti-inflammatory activity of oligomeric proanthocyanidins
(OPCs) has been observed in asthma, the mechanism responsible for these …

Cholera toxin (CT) is one of the most effective and widely studied mucosal adjuvants.
Although the ADP-ribosylating A subunit has been implicated in augmenting immune …

The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of
the immune system. LIGHT is a type II transmembrane protein belonging to the TNF family …