The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …

Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …

An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

Neuronal cell types are the nodes of neural circuits that determine the flow of information
within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides …

Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …

Significant evidence supports the view that dopamine shapes learning by encoding reward
prediction errors. However, it is unknown whether striatal targets receive tailored dopamine …

In the basal ganglia (BG), anatomically segregated and topographically organized
feedforward circuits are thought to modulate multiple behaviors in parallel. Although …

The cortex projects to the dorsal striatum topographically, to regulate behaviour,–, but
spiking activity in the two structures has previously been reported to have markedly different …

Deciding what to do and when to move is vital to our survival. Clinical and fundamental
studies have identified basal ganglia circuits as critical for this process. The main input …

Much of our present understanding of the function and operation of the basal ganglia rests
on models of anatomical connectivity derived from tract-tracing approaches in rodents and …