Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

Cell division is a complex process with high energy demands. However, how cells regulate
the generation of energy required for DNA synthesis and chromosome segregation is not …

As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated
levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic …

Background Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor
prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver …

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

The ability to quantify differentiation potential of single cells is a task of critical importance.
Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation …

Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …

Epithelial barriers of the skin, gastrointestinal tract, and airway serve common critical
functions, such as maintaining a physical barrier against environmental insults and …