Background The second consensus criteria for the diagnosis of multiple system atrophy
(MSA) are widely recognized as the reference standard for clinical research, but lack …

With the hope that disease-modifying treatments could target the molecular basis of
Parkinson's disease, even before the onset of symptoms, we propose a biologically based …

Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical
features, with α-synuclein pathology as the gold standard to establish the definitive …

Misfolded alpha-synuclein (αSyn) aggregates are a hallmark event in Parkinson's disease
(PD) and other synucleinopathies. Recently, αSyn seed amplification assays (αSyn-SAAs) …

Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for
Parkinson's disease (PD) and related synucleinopathies. They enable detection of seeding …

The diagnosis of Parkinsonian disorders is currently based on clinical criteria, which have
limited sensitivity until most dopaminergic neurons are lost. Here we show that …

Background Misfolded α‐synuclein (αSyn) aggregates (αSyn‐seeds) in cerebrospinal fluid
(CSF) are biomarkers for synucleinopathies such as Parkinson's disease (PD). αSyn‐seeds …

Orthostatic hypotension is an unusually large decrease in blood pressure on standing that
increases the risk of adverse outcomes even when asymptomatic. Improvements in …

Objective The purpose of this study was to determine the sensitivity and specificity of α‐
synuclein seed amplification assay (αSyn‐SAA) in antemortem and postmortem …

Abstract Introduction Alpha-synuclein (αSyn) aggregates are definite pathological hallmarks
of α-synucleinopathies. Seeding amplification assays (SAAs) have been developed to detect …