1, 2, 3-Triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens

C Deng, H Yan, J Wang, K Liu, B Liu, Y Shi - European Journal of …, 2022 - Elsevier
ESKAPE pathogens, as priority 1 and 2 pathogens, are prevalent infectious agents
associated with high morbidity and mortality. ESKAPE can cause broad-spectrum diseases …

Comprehensive Review on the Synthesis of [1,2,3]Triazolo[1,5‐a]Quinolines

GP Da Costa, M Sacramento… - The Chemical …, 2024 - Wiley Online Library
This report outlines the evolution and recent progress about the different protocols to
synthesize the N‐heterocycles fused hybrids, specifically [1, 2, 3] triazolo [1, 5‐a] quinoline …

Synthesis of novel acylated and esterified ciprofloxacin derivatives as efficient anticancer and antimicrobial agents

GM Alasadi, Z Al-Obaidi - Frontiers in Materials, 2023 - frontiersin.org
Nowadays, various factors enhance the resistance of some microbes to antibiotics. Irrational
antibiotic use is considered an example of such factors. Therefore, the synthesis and …

Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DNA/BSA Interaction and Molecular Docking Studies of 2-(6-(4-chlorophenyl)-1, 2, 4-triazin-3-yl) quinoline

T Göktürk, T Zengin, T Hökelek, CG Topkaya… - Journal of Molecular …, 2023 - Elsevier
We reported herein a new 1, 2, 4-triazine derivative, 2-(6-(4-chlorophenyl)-1, 2, 4-triazin-3-
yl) quinoline, synthesized by cyclization of p‑chloro isonitrosophenylhydrazine with 2 …

Design, synthesis and molecular docking study of novel quinoline–triazole molecular hybrids as anticancer agents

RD Bakale, AN Bhagat, UV Mhetre, SV Londhe… - Journal of Molecular …, 2025 - Elsevier
A series of novel thirty-three quinoline-triazole molecular hybrids were designed and
synthesized via Copper catalyzed azide-alkyne cycloaddition (CuAAC) strategy. The in-vitro …

Click chemistry beyond metal‐catalyzed cycloaddition as a remarkable tool for green chemical synthesis of antifungal medications

A Tahghighi, P Azerang - Chemical Biology & Drug Design, 2024 - Wiley Online Library
Click chemistry is widely used for the efficient synthesis of 1, 4‐disubstituted‐1, 2, 3‐triazole,
a well‐known scaffold with widespread biological activity in the pharmaceutical sciences. In …

Synthesis of 4-(3-(1-substituted/unsubstituted-phenyl-1H-1, 2, 3-triazole-4-yl) propoxy) benzaldehydes: In Vitro Antimicrobial, Antimalarial Activities and In silico …

MA Al-Salehi, MP Parmar, DP Rajani, HM Patel… - Journal of Molecular …, 2024 - Elsevier
In this work, we have developed new derivatives of 4-(3-(1-substituted/unsubstituted phenyl-
1H-1, 2, 3-triazol-4-yl) propoxy) benzaldehydes 3 (ao) in good to excellent yield through the …

[HTML][HTML] Quinoline: A versatile bioactive scaffold and its molecular hybridization

IA Bala, OF Al Sharif, AM Asiri, RM El-Shishtawy - Results in Chemistry, 2024 - Elsevier
Quinolines have become essential to many drugs, including broad-spectrum antibiotics,
antivirus, antitubercular, and antimalarial agents. Owing to their importance in medicinal and …

Cu‐Catalyzed Synthesis of Coumarin‐1, 2, 3‐Triazole Hybrids connected with Quinoline or Pyridine Framework

MD Douka, IM Sigala, E Nikolakaki, KC Prousis… - …, 2024 - Wiley Online Library
Abstract Coumarin‐1, 2, 3‐triazole hybrids connected to quinoline or pyridine framework
have been synthesized in good to excellent yield by the 1, 3‐dipolar azide alkyne …

Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study

K Marciniec, Z Rzepka, E Chrobak, S Boryczka… - Molecules, 2023 - mdpi.com
Cancer cells need to carefully regulate their metabolism to keep them growing and dividing
under the influence of different nutrients and oxygen levels. Muscle isoform 2 of pyruvate …