Multi-omics approaches to define calcific aortic valve disease pathogenesis
Calcific aortic valve disease sits at the confluence of multiple world-wide epidemics of aging,
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
obesity, diabetes, and renal dysfunction, and its prevalence is expected to nearly triple over …
Emerging tools and best practices for studying gut microbial community metabolism
C Noecker, PJ Turnbaugh - Nature Metabolism, 2024 - nature.com
The human gut microbiome vastly extends the set of metabolic reactions catalysed by our
own cells, with far-reaching consequences for host health and disease. However, our …
own cells, with far-reaching consequences for host health and disease. However, our …
[HTML][HTML] Fundamental behaviors emerge from simulations of a living minimal cell
ZR Thornburg, DM Bianchi, TA Brier, BR Gilbert… - Cell, 2022 - cell.com
We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell
with a reduced genome of 493 genes that has retained few regulatory proteins or small …
with a reduced genome of 493 genes that has retained few regulatory proteins or small …
Systems biology and multi-omics integration: viewpoints from the metabolomics research community
The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …
metabolomics) is becoming increasingly popular in all facets of life science. Omics …
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …
framework for integrative analysis of experimental molecular systems biology data and …
Metabolic induction of trained immunity through the mevalonate pathway
Innate immune cells can develop long-term memory after stimulation by microbial products
during infections or vaccinations. Here, we report that metabolic signals can induce trained …
during infections or vaccinations. Here, we report that metabolic signals can induce trained …
The RCSB protein data bank: integrative view of protein, gene and 3D structural information
Abstract The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB
PDB, http://rcsb. org), the US data center for the global PDB archive, makes PDB data freely …
PDB, http://rcsb. org), the US data center for the global PDB archive, makes PDB data freely …
Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity
Induction of trained immunity (innate immune memory) is mediated by activation of immune
and metabolic pathways that result in epigenetic rewiring of cellular functional programs …
and metabolic pathways that result in epigenetic rewiring of cellular functional programs …
BiGG Models: A platform for integrating, standardizing and sharing genome-scale models
Genome-scale metabolic models are mathematically-structured knowledge bases that can
be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can …
be used to predict metabolic pathway usage and growth phenotypes. Furthermore, they can …
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …