[HTML][HTML] Hydrogel-enabled, local administration and combinatorial delivery of immunotherapies for cancer treatment

A Erfani, AE Diaz, PS Doyle - Materials Today, 2023 - Elsevier
Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

Biomaterial-Based Sustained-Release Drug Formulations for Localized Cancer Immunotherapy

K Mujahid, I Rana, IH Suliman, Z Li, J Wu… - ACS Applied Bio …, 2023 - ACS Publications
Cancer immunotherapy has revolutionized clinical cancer treatments by taking advantage of
the immune system to selectively and effectively target and kill cancer cells. However …

Implantable, 3D-printed alginate scaffolds with bismuth sulfide nanoparticles for the treatment of local breast cancer via enhanced radiotherapy

B Colak, YN Ertas - ACS Applied Materials & Interfaces, 2024 - ACS Publications
Surgical removal of tumor tissue remains the primary clinical approach for addressing breast
cancer; however, complete tumor excision is challenging, and the remaining tumor cells can …

Orthogonal Gelations to Synthesize Core–Shell Hydrogels Loaded with Nanoemulsion‐Templated Drug Nanoparticles for Versatile Oral Drug Delivery

L Attia, LH Chen, PS Doyle - Advanced Healthcare Materials, 2023 - Wiley Online Library
Hydrophobic active pharmaceutical ingredients (APIs) are ubiquitous in the drug
development pipeline, but their poor bioavailability often prevents their translation into drug …

Injectable hydrogel formulations: Design, synthesis and applications for subcutaneous delivery–A comprehensive review

S Sarvepalli, HP Kandagatla - European Polymer Journal, 2024 - Elsevier
Subcutaneous route of administration presents a promising solution to address the
challenges encountered with other drug delivery routes. Injectable hydrogel formulations …

Landscape of Subcutaneous Administration Strategies for Monoclonal Antibodies in Oncology

G Jacquot, P Lopez Navarro, C Grange… - Advanced …, 2024 - Wiley Online Library
In recent decades, subcutaneous (SC) administration of monoclonal antibodies (mAbs) has
emerged as a promising alternative to intravenous delivery in oncology, offering comparable …

Biopharmaceutical drug delivery and phototherapy using protein crystals

R Zhou, J Qu, X Liu, F Lin, TY Ohulchanskyy… - Advanced Drug Delivery …, 2024 - Elsevier
Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for
their high specificity and efficacy, fundamentally transforming disease treatment paradigms …

Aerosolization of poly (sulfobetaine) microparticles that encapsulate therapeutic antibodies

S Xie, A Erfani, S Manouchehri, J Ramsey… - Biomaterials Advances, 2024 - Elsevier
Pulmonary delivery of protein therapeutics poses significant challenges that have not been
well addressed in the research literature or practice. In fact, there is currently only one …

[HTML][HTML] Injectable hydrogel particles for amorphous solid formulation of biologics

A Erfani, P Reichert, CN Narasimhan, PS Doyle - Iscience, 2023 - cell.com
The fast pace of breakthroughs in cancer immunotherapy, combined with the new paradigm
of moving toward high-concentration dosages and combinatorial treatments, is generating …

Industry update covering March 2023

I Simpson - Therapeutic Delivery, 2023 - Taylor & Francis
Industry update covering March 2023 | Therapeutic Delivery Future Science Logo Search
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