Evaluation of MTT heterogeneity of perfusion CT imaging in the early brain injury phase: an insight into aSAH pathopysiology

BB Hofmann, I Fischer, DM Donaldson, Y Abusabha… - Brain Sciences, 2023 - mdpi.com
The concept of early brain injury (EBI) is based on the assumption of a global reduction in
brain perfusion following aneurysmal subarachnoid hemorrhage (aSAH). However, the …

Evaluation of FRESH scores in predicting outcome and quality of life after aneurysmal subarachnoid haemorrhage in a European patient cohort

BB Hofmann, EP Gundlach, I Fischer, S Muhammad… - Acta …, 2024 - Springer
Background Despite aneurysmal subarachnoid haemorrhage (aSAH) patients often
experiencing physical and mental disabilities impacting their quality of life (QoL), routine …

Clinical outcome prediction of early brain injury in aneurysmal subarachnoid hemorrhage: the SHELTER-score

BB Hofmann, DM Donaldson, M Neyazi, Y Abusabha… - Neurocritical Care, 2024 - Springer
Background Despite intensive research on preventing and treating vasospasm and delayed
cerebral ischemia in aneurysmal subarachnoid hemorrhage (aSAH), mortality and morbidity …

[HTML][HTML] Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage

H Suzuki, H Nakajima, T Ichikawa, R Yasuda… - Brain …, 2024 - Elsevier
Objective This retrospective study aimed to analyze the prospectively collected data of
computed tomography (CT) perfusion imaging and to examine if clazosentan add-on …

Initial Temporal Muscle Thickness and Area: Poor Predictors of Neurological Outcome in Aneurysmal Subarachnoid Hemorrhage in a Central European Patient …

C Karadag, MA Kamp, I Fischer, HD Boogaarts… - Journal of Clinical …, 2023 - mdpi.com
The temporalis muscle area (TMA) has been proclaimed as a surrogate parameter for
estimating skeletal muscle mass. Pilot studies in Asian populations suggested temporal …

Revisiting the WFNS Score: Native Computed Tomography Imaging Improves Identification of Patients With “False Poor Grade” Aneurysmal Subarachnoid …

BB Hofmann, I Fischer, M Neyazi, C Karadag… - …, 2024 - journals.lww.com
METHODS: We retrospectively analyzed daily WFNS scores from admission until day 7 in
535 aSAH patients and evaluated their predictive value for the modified Rankin Scale at …

Novel Insights into Pathophysiology of Delayed Cerebral Ischemia: Effects of Current Rescue Therapy on Microvascular Perfusion Heterogeneity

BB Hofmann, C Karadag, C Rubbert, S Schieferdecker… - Biomedicines, 2023 - mdpi.com
General microvascular perfusion and its heterogeneity are pathophysiological features of
delayed cerebral ischemia (DCI) that are gaining increasing attention. Recently, CT …

Comparison of the Effects of Blood Pressure Parameters on Rebleeding and Outcomes in Unsecured Aneurysmal Subarachnoid Hemorrhage

A Haripottawekul, EM Persad-Paisley, S Paracha… - World Neurosurgery, 2024 - Elsevier
Background Elevated systolic blood pressure (SBP) has been linked to preprocedural
rebleeding risk and poor outcome in patients with aneurysmal subarachnoid hemorrhage …

Cerebral Autoregulation: Don't go with the Flow, be the Flow; Author′ s Response

BB Hofmann, C Rubbert, K Beseoglu - Neurocritical Care, 2023 - Springer
Dear editor, We would like to thank Ayasse et al. for their interest in our article “Blood
Pressure Affects the Early CT Perfusion Imaging in Patients with aSAH Reflecting Early …

Cerebral Autoregulation: Don't go with the Flow, be the Flow

T Ayasse, E Manquat, A Hermans-Didier, S Gaugain… - Neurocritical Care, 2023 - Springer
Dear editor, The determination of the appropriate mean arterial pressure (MAP) is the
cornerstone of the optimization of brain perfusion in critically ill patients with acute brain …