Understanding the chemical exposome during fetal development and early childhood: a review

M Krausová, D Braun… - Annual Review of …, 2023 - annualreviews.org
Early human life is considered a critical window of susceptibility to external exposures.
Infants are exposed to a multitude of environmental factors, collectively referred to as the …

Review of the environmental prenatal exposome and its relationship to maternal and fetal health

JE Rager, J Bangma, C Carberry, A Chao… - Reproductive …, 2020 - Elsevier
Environmental chemicals comprise a major portion of the human exposome, with some
shown to impact the health of susceptible populations, including pregnant women and …

Evidence for the presence of air pollution nanoparticles in placental tissue cells

NM Liu, L Miyashita, BA Maher, G McPhail… - Science of The Total …, 2021 - Elsevier
Inhaled particulate matter (PM) from combustion-and friction-sourced air pollution adversely
affects organs distant from the lung. A putative mechanism for the remote effect of inhaled …

2023 HRS expert consensus statement on the management of arrhythmias during pregnancy

JA Joglar, S Kapa, EV Saarel, AM Dubin, B Gorenek… - Heart Rhythm, 2023 - Elsevier
This international multidisciplinary expert consensus statement is intended to provide
comprehensive guidance that can be referenced at the point of care to cardiac …

Orthogonal design of experiments for engineering of lipid nanoparticles for mRNA delivery to the placenta

HC Safford, KL Swingle, HC Geisler, AG Hamilton… - Small, 2024 - Wiley Online Library
During healthy pregnancy, the placenta develops to allow for exchange of nutrients and
oxygen between the mother and the fetus. However, placental dysregulation can lead to …

[HTML][HTML] Healthy and diseased placental barrier on-a-chip models suitable for standardized studies

G Rabussier, I Bünter, J Bouwhuis, C Soragni… - Acta Biomaterialia, 2023 - Elsevier
Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the
leading causes of maternal and perinatal morbidity in the world. Its fundamental …

Rational design of nanomedicine for placental disorders: birthing a new era in women's reproductive health

HC Geisler, HC Safford, MJ Mitchell - Small, 2024 - Wiley Online Library
The placenta is a transient organ that forms during pregnancy and acts as a biological
barrier, mediating exchange between maternal and fetal circulation. Placental disorders …

Predicting human fetal drug exposure through maternal‐fetal PBPK modeling and in vitro or ex vivo studies

A Balhara, AR Kumar… - The Journal of Clinical …, 2022 - Wiley Online Library
Medication (drug) use in human pregnancy is prevalent. Determining fetal safety and
efficacy of drugs is logistically challenging. However, predicting (not measuring) fetal drug …

[HTML][HTML] Essential trace elements in placental tissue and risk for fetal neural tube defects

S Yin, C Wang, J Wei, D Wang, L Jin, J Liu… - Environment …, 2020 - Elsevier
This study examined the associations between concentrations of cobalt (Co), iron (Fe),
manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn) in placental tissue and …

[HTML][HTML] Dynamic placenta-on-a-chip model for fetal risk assessment of nanoparticles intended to treat pregnancy-associated diseases

S Shojaei, MS Ali, M Suresh, T Upreti… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Pregnant women often have to take medication either for pregnancy-related diseases or for
previously existing medical conditions. Current maternal medications pose fetal risks due to …