Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …

Itaconic acid is produced by immune responsive gene 1 (IRG1)-coded enzyme in activated
macrophages and known to play an important role in metabolism and immunity. In this study …

Innate sensing of pathogens by pattern-recognition receptors (PRRs) plays essential roles in
the innate discrimination between self and non-self components, leading to the generation …

Immune cell activation is a stringently regulated process, as exaggerated innate and
adaptive immune responses can lead to autoinflammatory and autoimmune diseases …

A20 is a potent anti-inflammatory protein, acting by inhibiting nuclear factor κB (NF-κB)
signaling and inflammatory gene expression and/or by preventing cell death. Mutations in …

Many chronic pain conditions show sex differences in their epidemiology. This could be
attributed to sex-dependent differential expression of genes (DEGs) involved in nociceptive …

Dysregulation of transcription factors has been implicated in a variety of human diseases.
However, these proteins have traditionally been regarded as undruggable and only a …

Neuroinflammation and mitochondrial dysfunction, key mechanisms in the pathogenesis of
Parkinson's disease (PD), are usually explored independently. Loss‐of‐function mutations …

The nuclear factor κB (NF-κΒ) subunits RelA, RelB, cRel, p50, and p52 are each critical for B
cell development and function. To systematically characterize their responses to canonical …