Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

Ion channels are crucial components of cellular excitability and are involved in many
neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Despite the dramatic increase in human lifespan over the past century, there remains
pronounced variability in “health‐span,” or the period of time in which one is generally …

Freeman-Sheldon syndrome, or distal arthrogryposis type 2A (DA2A), is an autosomal-
dominant condition caused by mutations in MYH3 and characterized by multiple congenital …

Ferroptotic cell death results from glutathione peroxidase 4 (GPX4) inactivation and/or
glutathione (GSH) depletion. Elevated GSH levels are often found in multidrug‐resistant …

PERIOD 1 (PER1) is a circadian clock transcription factor that is regulated by aldosterone, a
hormone that increases blood volume and Na+ retention to increase blood pressure. Male …

The circadian clock is integral to the maintenance of daily rhythms of many physiological
outputs, including blood pressure. Our laboratory has previously demonstrated the …

Background Breast cancer remains a leading cause of death in women and novel imaging
biomarkers are urgently required. Here, we demonstrate the diagnostic and treatment …

Summary A cation channel NCA/UNC-79/UNC-80 affects neuronal activity. We report here
the identification of a conserved endoplasmic reticulum protein NLF-1 (NCA localization …