Pragmatic coarse-graining of proteins: models and applications
The molecular details involved in the folding, dynamics, organization, and interaction of
proteins with other molecules are often difficult to assess by experimental techniques …
proteins with other molecules are often difficult to assess by experimental techniques …
On the specificity of protein–protein interactions in the context of disorder
With the increased focus on intrinsically disordered proteins (IDPs) and their large
interactomes, the question about their specificity—or more so on their multispecificity—arise …
interactomes, the question about their specificity—or more so on their multispecificity—arise …
[HTML][HTML] Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein
Highly charged intrinsically disordered proteins are essential regulators of chromatin
structure and transcriptional activity. Here we identify a surprising mechanism of molecular …
structure and transcriptional activity. Here we identify a surprising mechanism of molecular …
Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation
C Pascal, J Zonszain, O Hameiri, C Gargi-Levi… - Molecular Cell, 2023 - cell.com
Histones shape chromatin structure and the epigenetic landscape. H1, the most diverse
histone in the human genome, has 11 variants. Due to the high structural similarity between …
histone in the human genome, has 11 variants. Due to the high structural similarity between …
Affinity of disordered protein complexes is modulated by entropy–energy reinforcement
The association between two intrinsically disordered proteins (IDPs) may produce a fuzzy
complex characterized by a high binding affinity, similar to that found in the ultrastable …
complex characterized by a high binding affinity, similar to that found in the ultrastable …
From Nucleosomes to Compartments: Physicochemical Interactions Underlying Chromatin Organization
Chromatin organization plays a critical role in cellular function by regulating access to
genetic information. However, understanding chromatin folding is challenging due to its …
genetic information. However, understanding chromatin folding is challenging due to its …
Genome modeling: from chromatin fibers to genes
The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …
many creative modeling studies. The specific model/simulation technique combination …
Unraveling linker histone interactions in nucleosomes
Considerable progress has been made recently in defining the interactions of linker histones
(H1s) within nucleosomes. Major advancements include atomic resolution structures of the …
(H1s) within nucleosomes. Major advancements include atomic resolution structures of the …
Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
R Hirano, H Ehara, T Kujirai, T Uejima… - Nature …, 2022 - nature.com
In chromatin, linker histone H1 binds to nucleosomes, forming chromatosomes, and
changes the transcription status. However, the mechanism by which RNA polymerase II …
changes the transcription status. However, the mechanism by which RNA polymerase II …
The role of cryptic ancestral symmetry in histone folding mechanisms across Eukarya and Archaea
Histones compact and store DNA in both Eukarya and Archaea, forming heterodimers in
Eukarya and homodimers in Archaea. Despite this, the folding mechanism of histones …
Eukarya and homodimers in Archaea. Despite this, the folding mechanism of histones …