Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated
median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly …

The aging process is known to be associated with heightened oxidative stress and related
systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising …

Burnout, the outcome of prolonged stress or frustration, manifests as both mental and
physical fatigue affecting over half of healthcare workers. This article will discuss the …

Background Currently, telomere length is known to reflect the replication potential and
longevity of cells, and many studies have reported that telomere length is associated with …

Telomeres are structures located at the ends of chromosomes associated with proteins, from
the shelterin complex, which are responsible for the protection and preservation of the …

A telomere consists of repeated DNA sequences (TTAGGG) n as part of a nucleoprotein
structure at the end of the linear chromosome, and their progressive shortening induces …

Aging is a complex biological process characterized by the gradual decline of cellular
functions, increased susceptibility to diseases, and impaired stress responses. Hypoxia …

Telomere maintenance plays important roles in genome stability and cell proliferation.
Tumor cells acquire replicative immortality by activating a telomere-maintenance …

Mouse models have been widely used in the research of human diseases. Aging, just as
cancer, is influenced by the interaction of various genetic and environmental factors …

Abnormal trinucleotide expansions cause rare disorders that compromise quality of life and,
in some cases, lifespan. In particular, the expansions of the CGG-repeats stretch at the 5' …