The solubility behaviour of drugs remains one of the most exigent aspects in formulation
development. These days, the number of new chemical entities has dramatically increased …

Atorvastatin has low aqueous solubility resulting in low oral bioavailability (12%) and thus
presents a challenge in formulating a suitable dosage form. To improve the aqueous …

Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin
layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It …

Co-amorphization has recently been shown to be a promising approach for stabilizing
amorphous drugs and improving the dissolution rate of poorly water-soluble drugs. In this …

The aim of this study was to encapsulate an antihypertensive drug (valsartan) within
polyester microparticles, namely constituted of poly (lactic acid)(PLA) and poly (ε …

BCS class II drugs pose challenging problems in their pharmaceutical product development
process because of their low solubility and dissolution rates. They require enhancement in …

Objective (s): Chronic hypertension is a pervasive morbidity and the leading risk factor for
cardiovascular diseases. Valsartan, as an antihypertensive drug, has low solubility and …

The purpose of this study was to investigate the effects of alkalizers in dissolution rate and
crystal structure of valsartan (VAL) in Poloxamer 407 (POX)-based solid dispersions (SD) …

For the quality evaluation of raw materials, the influence of various types of solvents on the
polymorphic crystallization behaviors and dissolution rates of two sources of valsartan (VAL) …

Nanostructured lipid carriers (NLCs), a lipid based colloidal carrier system, offer many
advantages such as increase the solubility, improves the bioavailability and therapeutic …