Virus pandemics have happened, are happening and will happen again. In recent decades,
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …

Nirmatrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro), is
clinically useful against infection with SARS-CoV-2 including its omicron variants. Since …

The approval of combination therapies with direct-acting antiviral (DAA) regimens has led to
significant progress in the field of hepatitis C virus (HCV) treatment. Although most patients …

Background & Aims Voxilaprevir/velpatasvir/sofosbuvir (VOX/VEL/SOF) is highly effective for
re-treatment of direct-acting antiviral (DAA)-experienced patients with chronic HCV infection …

Hepatitis C is the most common liver disease caused by Hepatitis C virus (HCV), and can
evolve into serious health problems eg cirrhosis and hepatocellular carcinoma. Nowadays …

Populations of RNA viruses are composed of complex and dynamic mixtures of variant
genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV …

Epidemics and pandemics have occurred since the beginning of time, resulting in millions of
deaths. Many such disease outbreaks are caused by viruses. Some viruses, particularly …

We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting
Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant …

Mutant spectra of RNA viruses are important to understand viral pathogenesis and response
to selective pressures. There is a need to characterize the complexity of mutant spectra in …

Background: The hepatitis C virus has a high mutation rate, which results in the emergence
of resistance-associated substitutions (RASs). Despite direct-acting antivirals (DAAs) efforts …